Strong Against
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Unless there's a huge healing disparity or the other team has crazy damage builds, always assume you're winning the tank damage trade...SWING, then peel to squishies when available. If against a tank with lots of armor, swap in [Codebreaker] and maybe [Shieldbuster] Round 4/5. Remember that more Move Speed = more chances to do damage and get money; more Attack Speed = more swings to heal yourself.
If all enemies besides the tank are unreachable with melee or just too fast for Rein (Genji, Mercy, Lucio, Freja, etc.), swap to my Move Speed/Fire Strike build on Round 3 to catch up to them/snipe them while keeping the tank occupied: https://stadiumbuilds.io/build/ac5aeadc-a395-4cae-98dc-5757abb86ac8
PS, it goes without saying but play safe around right-click Cass/Weapon Power Reaper; hold your corners and catch them off guard after they use their roll/fade.
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